[HTML][HTML] Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer's disease

HM Albadrani, P Chauhan, S Ashique, MA Babu… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with
memory loss and a progressive decline in cognitive activity. The two major …

Investigating the potential therapeutic mechanisms of puerarin in neurological diseases

P Chauhan, K Wadhwa, R Mishra, S Gupta… - Molecular …, 2024 - Springer
Plants and their derived phytochemicals have a long history of treating a wide range of
illnesses for several decades. They are believed to be the origin of a diverse array of …

Biomaterial strategies for regulating the neuroinflammatory response

AN Galindo, DAF Rubio, MH Hettiaratchi - Materials Advances, 2024 - pubs.rsc.org
Injury and disease in the central nervous system (CNS) can result in a dysregulated
inflammatory environment that inhibits the repair of functional tissue. Biomaterials present a …

[HTML][HTML] Alzheimer's disease, obesity, and type 2 diabetes: focus on common neuroglial dysfunctions (critical review and new data on human brain and models)

A Toledano, A Rodríguez-Casado, MI Älvarez… - Brain Sciences, 2024 - mdpi.com
Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are
pathologies that affect millions of people worldwide. They have no effective therapy and are …

[HTML][HTML] From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders

E Duranti, C Villa - Biology, 2024 - mdpi.com
Simple Summary Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis
(ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), mainly impact the central …

Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

S Chib, BJ Dutta, R Chalotra, M Abubakar… - Phytotherapy …, 2024 - Wiley Online Library
With the passage of time, people step toward old age and become more prone to several
diseases associated with the age. One such is Alzheimer's disease (AD) which results into …

Cross-scale targeted remodeling of neurovascular and neurometabolic coupling in Alzheimer's disease by natural self-assembled SIRT1 activator

D Zhao, F Yang, Y Liu, M Cheng, Z Chen, C Ye… - Nano Today, 2024 - Elsevier
Chronic neuromicrovascular dysfunction and its induced multifaceted neuropathology
involving the interaction of cellular differential pathogenic mechanisms pose challenges to …

[HTML][HTML] Phytotherapy in Alzheimer's Disease—A Narrative Review

J Piekarz, N Picheta, O Burdan, M Kurek… - Biomedicines, 2024 - mdpi.com
Alzheimer's disease (AD) affects 50–70% of patients with dementia, making it the leading
cause of dementia. The condition is classified as a neurodegenerative, progressive and …

Overview of alkyl quercetin lipophenol synthesis and its protective effect against carbonyl stress involved in neurodegeneration

L Otaegui, J Lehoux, L Martin, L Givalois… - Organic & …, 2024 - pubs.rsc.org
Oxidative stress and carbonyl stress resulting from the toxicity of small aldehydes are part of
the detrimental mechanisms leading to neuronal cell loss involved in the progression of …

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions

AG Almutary, MY Begum, AK Kyada, S Gupta… - Ageing Research …, 2025 - Elsevier
The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the
development of therapies. Recently, neuroinflammation has been identified as a key …