A critical analysis of codon optimization in human therapeutics
VP Mauro, SA Chappell - Trends in molecular medicine, 2014 - cell.com
Codon optimization describes gene engineering approaches that use synonymous codon
changes to increase protein production. Applications for codon optimization include …
changes to increase protein production. Applications for codon optimization include …
Dynamic root exudate chemistry and microbial substrate preferences drive patterns in rhizosphere microbial community assembly
Like all higher organisms, plants have evolved in the context of a microbial world, sha**
both their evolution and their contemporary ecology. Interactions between plant roots and …
both their evolution and their contemporary ecology. Interactions between plant roots and …
Moderating the neutralist–selectionist debate: exactly which propositions are we debating, and which arguments are valid?
Half a century after its foundation, the neutral theory of molecular evolution continues to
attract controversy. The debate has been hampered by the coexistence of different …
attract controversy. The debate has been hampered by the coexistence of different …
The systemic imprint of growth and its uses in ecological (meta) genomics
Microbial minimal generation times range from a few minutes to several weeks. They are
evolutionarily determined by variables such as environment stability, nutrient availability …
evolutionarily determined by variables such as environment stability, nutrient availability …
Genome-wide analysis of codon usage bias in four sequenced cotton species
L Wang, H **ng, Y Yuan, X Wang, M Saeed, J Tao… - PloS one, 2018 - journals.plos.org
Codon usage bias (CUB) is an important evolutionary feature in a genome which provides
important information for studying organism evolution, gene function and exogenous gene …
important information for studying organism evolution, gene function and exogenous gene …
Codon usage bias in animals: disentangling the effects of natural selection, effective population size, and GC-biased gene conversion
Selection on codon usage bias is well documented in a number of microorganisms. Whether
codon usage is also generally shaped by natural selection in large organisms, despite their …
codon usage is also generally shaped by natural selection in large organisms, despite their …
Mutation and selection cause codon usage and bias in mitochondrial genomes of ribbon worms (Nemertea)
The phenomenon of codon usage bias is known to exist in many genomes and it is mainly
determined by mutation and selection. To understand the patterns of codon usage in …
determined by mutation and selection. To understand the patterns of codon usage in …
Strategies of codon optimization for high-level heterologous protein expression in microbial expression systems
AB Al-Hawash, X Zhang, F Ma - Gene Reports, 2017 - Elsevier
Codon optimization includes strategies in gene design engineering, which uses
synonymous codon changes to improve levels of protein production. Codon usage bias …
synonymous codon changes to improve levels of protein production. Codon usage bias …
Dietary nitrogen alters codon bias and genome composition in parasitic microorganisms
EA Seward, S Kelly - Genome biology, 2016 - Springer
Background Genomes are composed of long strings of nucleotide monomers (A, C, G and T)
that are either scavenged from the organism's environment or built from metabolic …
that are either scavenged from the organism's environment or built from metabolic …
[HTML][HTML] A new codon adaptation metric predicts vertebrate body size and tendency to protein disorder
The nearly neutral theory of molecular evolution posits variation among species in the
effectiveness of selection. In an idealized model, the census population size determines …
effectiveness of selection. In an idealized model, the census population size determines …