Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

As a highly conserved signaling network across different species, the Hippo pathway is
involved in various biological processes. Dysregulation of the Hippo pathway could lead to a …

Triple negative breast cancer (TNBC) is an aggressive disease which currently has no
effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 …

Abstract Background Bronchial premalignant lesions (PMLs) are composed primarily of cells
resembling basal epithelial cells of the airways, which through poorly understood …

YAP1 is a well-known core effector of the Hippo pathway in tumors, but its potential role in
osimertinib resistance remained unexplored. Our study provides evidence that YAP1 acts as …

As highly conserved among diverse species, Hippo signaling pathway regulates various
biological processes, including development, cell proliferation, stem cell function, tissue …

Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require
conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP …

The tumor suppressor PTEN (phosphatase and tensin homolog deleted in chromosome 10)
is genetically deleted or downregulated in many cancer types. Loss of PTEN protein …

Our work aimed to investigate the interactive roles of transforming growth factor β1 (TGF-β1),
ubiquitin-specific-processing protease 7 (USP7), and Yes-associated protein (YAP) in …

Background Liver cancer is the fifth leading cause of cancer death worldwide, but early
diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and …