Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Crosstalk between the circadian clock circuitry and the immune system

N Cermakian, T Lange, D Golombek… - Chronobiology …, 2013 - Taylor & Francis
Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions

H Huang, A Mehta, J Kalmanovich, A Anand… - Molecular biology …, 2023 - Springer
Background Circadian rhythm is characterised by daily variations in biological activity to
align with the light and dark cycle. These diurnal variations, in turn, influence physiological …

Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens

M Sertbas, KO Ulgen - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

The complex interplay of parasites, their hosts, and circadian clocks

P Carvalho Cabral, M Olivier… - Frontiers in Cellular and …, 2019 - frontiersin.org
Parasites have evolved various mechanisms to favor infection of their hosts and enhance
the success of the infection. In this respect, time-of-day effects were found during the course …

Circadian rhythms in infectious diseases and symbiosis

F Rijo-Ferreira, JS Takahashi - Seminars in cell & developmental biology, 2022 - Elsevier
Timing is everything. Many organisms across the tree of life have evolved timekee**
mechanisms that regulate numerous of their cellular functions to optimize timing by …

Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico Approach

SA Geronikolou, A Pavlopoulou… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Obesity, a chronic, preventable disease, has significant comorbidities that are associated
with a great human and financial cost for society. The aim of the present work is to …

[HTML][HTML] Clockwork intruders: Do parasites manipulate their hostsʼ circadian rhythms?

S Boy-Waxman, M Olivier, N Cermakian - Current Research in Parasitology …, 2024 - Elsevier
Most organisms have developed circadian clocks to adapt to 24-hour cycles in the
environment. These clocks have become crucial for modulating and synchronizing complex …

Introduction to biological rhythms: A brief history of chronobiology and its relevance to parasite immunology

LM Ince - Parasite Immunology, 2022 - Wiley Online Library
Almost every living organism on earth is exposed to a fluctuating environment, for example,
light: dark cycles, food availability and seasonal photoperiods. Most species have therefore …

A time to kill, and a time to heal: pathophysiological interactions between the circadian and the immune systems

MJ Leone, JJ Chiesa, L Marpegan… - … Mini Reviews (PMR), 2007 - sedici.unlp.edu.ar
Current clinical data show a strong correlation between time of day and illness manifestation
or immune activity. For example, symptoms of rheumatoid arthritis occur during the morning …