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Nanozymes for regenerative medicine
Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …
Understanding the bone in cancer metastasis
The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
Y Zhou, D Yang, Q Yang, X Lv, W Huang… - Nature …, 2020 - nature.com
Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …
Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …
Inflammation, fracture and bone repair
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …
[HTML][HTML] Structural and metabolic changes in bone
Simple Summary Bone is an extremely metabolically active tissue that is regenerated and
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …
Physiological bone remodeling: systemic regulation and growth factor involvement
Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …
formation and resorption. The balance between the two phases is crucial for sustaining bone …
Silk fibroin as biomaterial for bone tissue engineering
Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its
unique mechanical properties, tunable biodegradation rate and the ability to support the …
unique mechanical properties, tunable biodegradation rate and the ability to support the …
The effect of inflammation on bone
Bone remodeling is the continual process to renew the adult skeleton through the sequential
action of osteoblasts and osteoclasts. Nuclear factor RANK, an osteoclast receptor, and its …
action of osteoblasts and osteoclasts. Nuclear factor RANK, an osteoclast receptor, and its …
[HTML][HTML] Obesity and bone health: a complex relationship
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old …
especially in those with a higher visceral adipose tissue content. This contradicts the old …