Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the
extracellular matrix. Talins control the activation state of integrins, link integrins to …

Studies of cancer cell migration have found two modes: one that is protease-independent,
requiring micron-sized pores or channels for cells to squeeze through, and one that is …

Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to
successful T cell-based immunotherapies. Here, we describe an innovative platform to …

Eosinophils are potent sources of inflammatory and toxic mediators, yet they reside in large
numbers in the healthy intestine without causing tissue damage. We show here that …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

Focal adhesions form liquid-like assemblies around activated integrin receptors at the
plasma membrane. How they achieve their flexible properties is not well understood. Here …

Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

During the metastatic progression, invading cells might achieve degradation and
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …

In brain metastasis, cancer cells remain in close contact with the existing vasculature and
can use vessels as migratory paths—a process known as vessel co-option. However, the …