Characterization of the SARS‐CoV‐2 E protein: sequence, structure, viroporin, and inhibitors
Y Cao, R Yang, I Lee, W Zhang, J Sun, W Wang… - Protein …, 2021 - Wiley Online Library
The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …
[HTML][HTML] COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
Coronaviruses have caused several zoonotic infections in the past two decades, leading to
significant morbidity and mortality globally. Balanced regulation of cell death and …
significant morbidity and mortality globally. Balanced regulation of cell death and …
Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology
M Levin - Cellular and Molecular Life Sciences, 2023 - Springer
A critical aspect of evolution is the layer of developmental physiology that operates between
the genotype and the anatomical phenotype. While much work has addressed the evolution …
the genotype and the anatomical phenotype. While much work has addressed the evolution …
The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal
A Perrier, A Bonnin, L Desmarets, A Danneels… - Journal of Biological …, 2019 - ASBMB
Coronavirus M proteins represent the major protein component of the viral envelope. They
play an essential role during viral assembly by interacting with all of the other structural …
play an essential role during viral assembly by interacting with all of the other structural …
Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins
Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …
less, can be found in organisms of all domains of life, outnumbering annotated protein …
Origins of life: The Protein Folding Problem all over again?
How did specific useful protein sequences arise from simpler molecules at the origin of life?
This seemingly needle-in-a-haystack problem has remarkably close resemblance to the old …
This seemingly needle-in-a-haystack problem has remarkably close resemblance to the old …
The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury
Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …
related to TBI is first due to the direct injury and then to a secondary phase in which …
The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH
Key points We report a novel method for the transient expression of SARS‐CoV‐2 envelope
(E) protein in intracellular organelles and the plasma membrane of mammalian cells and …
(E) protein in intracellular organelles and the plasma membrane of mammalian cells and …
Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis
C Castaño-Rodriguez, JM Honrubia… - MBio, 2018 - Am Soc Microbiol
Viroporins are viral proteins with ion channel (IC) activity that play an important role in
several processes, including virus replication and pathogenesis. While many coronaviruses …
several processes, including virus replication and pathogenesis. While many coronaviruses …