Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Lipolysis: cellular mechanisms for lipid mobilization from fat stores

GF Grabner, H **e, M Schweiger, R Zechner - Nature metabolism, 2021 - nature.com
The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Bioorthogonal chemistry

SL Scinto, DA Bilodeau, R Hincapie, W Lee… - Nature Reviews …, 2021 - nature.com
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Goods and bads of the endocannabinoid system as a therapeutic target: lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - Elsevier
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

[HTML][HTML] Greasing the wheels of the cancer machine: the role of lipid metabolism in cancer

MT Snaebjornsson, S Janaki-Raman, A Schulze - Cell metabolism, 2020 - cell.com
Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …

[HTML][HTML] Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues

D Casares, PV Escribá, CA Rosselló - International journal of molecular …, 2019 - mdpi.com
Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Lipid droplets: platforms with multiple functions in cancer hallmarks

ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

The adipocyte microenvironment and cancer

A Mukherjee, AJ Bilecz, E Lengyel - Cancer and Metastasis Reviews, 2022 - Springer
Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

Morbidity and mortality associated with obesity

M Abdelaal, CW le Roux… - Annals of translational …, 2017 - pmc.ncbi.nlm.nih.gov
Obesity and its repercussions constitute an important source of morbidity, impaired quality of
life and its complications can have a major bearing on life expectancy. The present article …