Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial
studies of its enzymatic activity and function took place in an environment focused on …

Estrogens are synthesized by the aromatase enzyme encoded by the Cyp19a1 gene, which
contains an unusually large regulatory region. In most mammals, aromatase expression is …

The role of estrogens in antitumor immunity remains poorly understood. Here, we show that
estrogen signaling accelerates the progression of different estrogen-insensitive tumor …

Ovarian cancer is the fifth most frequently occurring cancer among women and leading
cause of gynecological cancer deaths in North America. Although the etiology of ovarian …

Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian
cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair …

Triple negative breast cancer (TNBC) is a type of aggressive breast cancer lacking the
expression of estrogen receptors (ER), progesterone receptors (PR) and human epidermal …

Background BRCA1-mutant breast tumors are typically estrogen receptor alpha (ERα)
negative, whereas most sporadic tumors express wild-type BRCA1 and are ERα positive …

BRCA1 mainly acts as a tumor suppressor and BRCA1 mutation correlates with increased
cancer risk. Although it is well recognized that BRCA1 related tumorigenesis is mainly …

Germline mutations of human breast cancer-associated gene 1 (BRCA1) predispose women
to breast and ovarian cancers. In mice, over 20 distinct mutations, including null …

Purpose Current concepts regarding estrogen and its mechanistic effects on breast cancer
in women are evolving. This article reviews studies that address estrogen-mediated breast …