A recent flurry of reports correlates replication timing (RT) with mutation rates during both
evolution and cancer. Specifically, point mutations and copy number losses correlate with …

Human genetic variation is distributed nonrandomly across the genome, though the
principles governing its distribution are only partially known. DNA replication creates …

Mutational heterogeneity must be taken into account when reconstructing evolutionary
histories, calibrating molecular clocks, and predicting links between genes and disease …

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA)
replication program. Inaccuracies in DNA replication lead to the increased acquisition of …

Eukaryotic genome replication is stochastic, and each cell uses a different cohort of
replication origins. We demonstrate that interpreting high-resolution Saccharomyces …

DNA replication is a dynamic process that occurs in a temporal order along each of the
chromosomes. A consequence of the temporally coordinated activation of replication origins …

The mammalian DNA replication timing (RT) program is crucial for the proper functioning
and integrity of the genome. The best-known mechanism for controlling RT is the …

The spatio-temporal program of genome replication across eukaryotes is thought to be
driven both by the uneven loading of pre-replication complexes (pre-RCs) across the …

During S phase, the entire genome must be precisely duplicated, with no sections of DNA
left unreplicated. Here, we develop a simple mathematical model to describe the probability …

The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …