Advances in NK cell therapy for brain tumors

J Fares, ZB Davis, JS Rechberger, SA Toll… - NPJ Precision …, 2023 - nature.com
Despite advances in treatment regimens that comprise surgery, chemotherapy, and
radiation, outcome of many brain tumors remains dismal, more so when they recur. The …

Immune cells as tumor drug delivery vehicles

F Combes, E Meyer, NN Sanders - Journal of Controlled Release, 2020 - Elsevier
This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …

Magneto-activation and magnetic resonance imaging of natural killer cells labeled with magnetic nanocomplexes for the treatment of solid tumors

T Sim, B Choi, SW Kwon, KS Kim, H Choi, A Ross… - ACS …, 2021 - ACS Publications
Natural killer (NK) cell-based immunotherapy has been considered a promising cell-based
cancer treatment strategy with low side effects for early tumors and metastasis. However, the …

Multifunctional nanoparticles for genetic engineering and bioimaging of natural killer (NK) cell therapeutics

KS Kim, JH Han, JH Park, HK Kim, SH Choi, GR Kim… - Biomaterials, 2019 - Elsevier
Abstract Recently, natural killer (NK)-based immunotherapy has attracted attention as a next-
generation cell-based cancer treatment strategy due to its mild side effects and excellent …

Molecular magnetic resonance imaging in cancer

M Haris, SK Yadav, A Rizwan, A Singh, E Wang… - Journal of translational …, 2015 - Springer
The ability to identify key biomolecules and molecular changes associated with cancer
malignancy and the capacity to monitor the therapeutic outcome against these targets is …

19F-MRI for monitoring human NK cells in vivo

MN Bouchlaka, KD Ludwig, JW Gordon, MP Kutz… - …, 2016 - Taylor & Francis
The availability of clinical-grade cytokines and artificial antigen-presenting cells has
accelerated interest in using natural killer (NK) cells as adoptive cellular therapy (ACT) for …

Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions

S Battella, MC Cox, A Santoni… - Journal of Leucocyte …, 2016 - academic.oup.com
Tumor-targeting mAb are widely used in the treatment of a variety of solid and hematopoietic
tumors and represent the first immunotherapeutic approach successfully arrived to the clinic …

Natural killer cell (NK-92MI)-based therapy for pulmonary metastasis of anaplastic thyroid cancer in a nude mouse model

L Zhu, XJ Li, S Kalimuthu, P Gangadaran… - Frontiers in …, 2017 - frontiersin.org
Objective Natural killer (NK) cells represent the third largest population of lymphocytes, and
they play an important role in immune surveillance against tumors. The lungs are a common …

Molecular imaging: a useful tool for the development of natural killer cell-based immunotherapies

P Gangadaran, BC Ahn - Frontiers in immunology, 2017 - frontiersin.org
Molecular imaging is a relatively new discipline that allows visualization, characterization,
and measurement of the biological processes in living subjects, including humans, at a …

Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI

BA Kennis, KA Michel, WB Brugmann… - Journal of neuro …, 2019 - Springer
Purpose Medulloblastoma (MB) is the most common malignant brain tumor in children.
Recent studies have shown the ability of natural killer (NK) cells to lyse MB cell lines in vitro …