Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …

Advances in genoty** and sequencing technologies, coupled with the development of
sophisticated statistical methods, have afforded investigators novel opportunities to define …

Most secretory proteins travel through a well-documented conventional secretion pathway
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …

Purpose: To assess the potential of whole-genome sequencing (WGS) to replicate and
augment results from conventional blood-based newborn screening (NBS). Methods …

BACKGROUND & AIMS: Pancreatic bicarbonate (HCO3−) secretion is important for a
healthy pancreas as well as digestive physiology. However, how human pancreatic duct …

With the completion of the human genome project, attention is now rapidly shifting towards
the study of individual genetic variation. The most abundant source of genetic variation in …

Acute pancreatitis and chronic pancreatitis are complex inflammatory disorders of the
pancreas with unpredictable severity, complications, and clinical courses. Growing evidence …

Large-scale, multilocus genetic association studies require powerful and appropriate
statistical-analysis tools that are designed to relate genotype and haplotype information to …

Over the past 20 years it has become evident that eukaryotic cells utilize both conventional
and unconventional pathways to deliver proteins to their target sites. Most proteins with a …

Induction of endoplasmic reticulum (ER)‐to‐Golgi blockade or ER stress induces Golgi
reassembly stacking protein (GRASP)‐mediated, Golgi‐independent unconventional cell …