Two facts about the hippocampus have been common currency among neuroscientists for
several decades. First, lesions of the hippocampus in humans prevent the acquisition of new …

This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based
on the notion that the brain is an inference machine that actively constructs hypotheses to …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

Current pathophysiological theories of schizophrenia highlight the role of altered brain
connectivity. This dysconnectivity could manifest 1) anatomically, through structural changes …

Synapses are crucial structures that mediate signal transmission between neurons in
complex neural circuits and display considerable morphological and electrophysiological …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

As key functional units in neural circuits, different types of neuronal synapses play distinct
roles in brain information processing, learning, and memory. Synaptic abnormalities are …

The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The
intracellular parasite can persist lifelong in the CNS within neurons modifying their function …

Interest in the therapeutic potential of non-invasive human brain stimulation has been
boosted by an improved understanding of the mechanisms of synaptic plasticity and the …