The benefits and pitfalls of machine learning for biomarker discovery

S Ng, S Masarone, D Watson, MR Barnes - Cell and tissue research, 2023 - Springer
Prospects for the discovery of robust and reproducible biomarkers have improved
considerably with the development of sensitive omics platforms that can enable …

Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review

CR Bain, PS Myles, T Corcoran, JM Dieleman - Anaesthesia, 2023 - Wiley Online Library
In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …

3D molecular generative framework for interaction-guided drug design

W Zhung, H Kim, WY Kim - Nature Communications, 2024 - nature.com
Deep generative modeling has a strong potential to accelerate drug design. However,
existing generative models often face challenges in generalization due to limited data …

Artificial-intelligence-led revolution of construction materials: From molecules to Industry 4.0

XQ Wang, P Chen, CL Chow, D Lau - Matter, 2023 - cell.com
Industry 4.0 promotes the transformation of manufacturing industry to intelligence, which
demands advances in materials, devices, and systems of the construction industry …

Reframing sepsis immunobiology for translation: towards informative subty** and targeted immunomodulatory therapies

M Shankar-Hari, T Calandra, MP Soares… - The Lancet …, 2024 - thelancet.com
Sepsis is a common and deadly condition. Within the current model of sepsis
immunobiology, the framing of dysregulated host immune responses into proinflammatory …

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

IA Stelzer, MS Ghaemi, X Han, K Ando… - Science translational …, 2021 - science.org
Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …

Where nanosensors meet machine learning: Prospects and challenges in detecting Disease X

YX Leong, EX Tan, SX Leong, CS Lin Koh… - ACS …, 2022 - ACS Publications
Disease X is a hypothetical unknown disease that has the potential to cause an epidemic or
pandemic outbreak in the future. Nanosensors are attractive portable devices that can swiftly …

Recent developments in machine learning for mass spectrometry

AG Beck, M Muhoberac, CE Randolph… - ACS Measurement …, 2024 - ACS Publications
Statistical analysis and modeling of mass spectrometry (MS) data have a long and rich
history with several modern MS-based applications using statistical and chemometric …

A review of mechanistic learning in mathematical oncology

J Metzcar, CR Jutzeler, P Macklin… - Frontiers in …, 2024 - frontiersin.org
Mechanistic learning refers to the synergistic combination of mechanistic mathematical
modeling and data-driven machine or deep learning. This emerging field finds increasing …

Heterogeneity and transcriptome changes of human CD8+ T cells across nine decades of life

J Lu, R Ahmad, T Nguyen, J Cifello, H Hemani… - Nature …, 2022 - nature.com
The decline of CD8+ T cell functions contributes to deteriorating health with aging, but the
mechanisms that underlie this phenomenon are not well understood. We use single-cell …