Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Motivation G-quadruplexes (G4s) are one of the non-B DNA structures easily observed in
vitro and assumed to form in vivo. The latest experiments with G4-specific antibodies and G4 …

Somatic mutations show variation in density across cancer genomes. Previous studies have
shown that chromatin organization and replication time domains are correlated with, and …

Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to
suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that …

DNA forms not only the canonical duplex structure but also non-canonical structures. Most
potential sequences that induce the formation of non-canonical structures are present in …

DNA can form several secondary structures besides the classic double helix: one that has
received much attention in recent years is the G-quadruplex (G4). This is a stable four …

Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative
torsional strain, which occurs during replication and transcription, and may lead to genomic …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …