According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

The specific recognition of protein surface elements is a fundamental challenge in the life
sciences. New developments in this field will form the basis of advanced therapeutic …

Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a
remarkably broad spectrum of biologic activities. MTs act as inhibitors of the self-assembly …

Molecular tweezers are open-ended, cavity-possessing U-shaped molecular architectures
with high potential for various applications in supramolecular chemistry. Their covalent …

A hallmark of Huntington's disease (HD) is a prolonged polyglutamine sequence in the
huntingtin protein and, correspondingly, an expanded cytosine, adenine, and guanine …

Native top-down mass spectrometry (MS) and ion mobility spectrometry (IMS) were applied
to characterize the interaction of a molecular tweezer assembly modulator, CLR01, with tau …

Intrinsically disordered proteins (IDPs) and regions of intrinsic disorder (IDRs) are abundant
in proteomes and are essential for many biological processes. Thus, they are often …

Regulation of specific protein function is of great importance for both research and
therapeutic development. Many small or large molecules have been developed to control …