Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Skeletal muscle stem cells have a central role in muscle growth and regeneration. They
reside as quiescent cells in resting muscle and in response to damage they transiently …

Highlights•Overview of the natural process of skeletal muscle regeneration.•Biomaterials
can be combined with muscle cells and other supporting cell types.•Biomaterials can …

The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate
decisions in both embryonic and adult life. Several aspects of stem cell maintenance are …

The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and
muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem …

Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle
wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident …

Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism
activated upon muscle damage and regulated by Notch signaling. In a family with autosomal …

Fibro-adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal
muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis …

Inhibition of Notch signaling via systemic drug administration triggers conversion of white
adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of …