Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022‏ - ahajournals.org
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Targeting the CCL2–CCR2 axis for atheroprotection

MK Georgakis, J Bernhagen, LH Heitman… - European heart …, 2022‏ - academic.oup.com
Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020‏ - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

[كتاب][B] Everyday data cultures

J Burgess, K Albury, A McCosker, R Wilken - 2022‏ - books.google.com
The AI revolution can seem powerful and unstoppable, extracting data from every aspect of
our lives and subjecting us to unprecedented surveillance and control. But at ground level …

[HTML][HTML] Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

K Pekayvaz, C Gold, P Hoseinpour, A Engel… - Immunity, 2023‏ - cell.com
Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such
as atherosclerosis. Because macrophages remove necrotic cells, defective macrophage …

Role of chemokine systems in cancer and inflammatory diseases

H Li, M Wu, X Zhao - MedComm, 2022‏ - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian randomization study

MK Georgakis, R Malik, D Gill… - Circulation: Genomic …, 2020‏ - ahajournals.org
Downregulation of IL-6 (interleukin-6) signaling has been proposed as a strategy for
lowering cardiovascular risk. Secondary analyses from CANTOS (Canakinumab Anti …

Emerging exosomes and exosomal MiRNAs in spinal cord injury

J Feng, Y Zhang, Z Zhu, C Gu, A Waqas… - Frontiers in cell and …, 2021‏ - frontiersin.org
Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with
considerable morbidity and mortality. This injury leads to short-and long-term variations in …

Targeting inflammation to reduce recurrent stroke

A Zietz, S Gorey, PJ Kelly, M Katan… - … Journal of Stroke, 2024‏ - journals.sagepub.com
Background: Approximately one in four stroke patients suffer from recurrent vascular events,
underlying the necessity to improve secondary stroke prevention strategies. Immune …

Mendelian randomization studies in stroke: exploration of risk factors and drug targets with human genetic data

MK Georgakis, D Gill - Stroke, 2021‏ - ahajournals.org
Elucidating the causes of stroke is key to develo** effective preventive strategies. The
Mendelian randomization approach leverages genetic variants related to an exposure of …