The interaction of tumor cells with platelets is a prerequisite for successful hematogenous
metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

At sites of vascular injury, platelets come into contact with the subendothelial extracellular
matrix which triggers their activation and the formation of a hemostatic plug. This process is …

Platelet adhesion, activation and aggregation on the exposed subendothelial extracellular
matrix (ECM) are essential for haemostasis, but may also lead to occlusion of diseased …

Abstract The glycoprotein VI (GPVI)-Fc receptor γ (FcRγ) chain is the major platelet signaling
receptor for collagen. Paradoxically, in a FeCl3 injury model, occlusion, but not initiation of …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Hemostasis and pathological thrombus formation are dynamic processes that require a co-
ordinated series of events involving platelet membrane receptors, bidirectional intracellular …

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …