Coumarin linked heterocyclic hybrids: a promising approach to develop multi target drugs for Alzheimer's disease

A Husain, K Al Balushi, MJ Akhtar, SA Khan - Journal of Molecular Structure, 2021 - Elsevier
Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for …

SK Yusufzai, MS Khan, O Sulaiman, H Osman… - Chemistry Central …, 2018 - Springer
Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display
interesting pharmacological properties. Several natural, synthetic and semisynthetic …

New organoruthenium (II) complexes containing N, X-donor (X= O, S) heterocyclic chelators: synthesis, spectral characterization, in vitro cytotoxicity and apoptosis …

G Kalaiarasi, MM Subarkhan, CKF Safwana… - Inorganica chimica …, 2022 - Elsevier
Four Schiff base ligands namely ((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene)
semicarbazide)(HL 1),((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene …

Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity

P Alam, AZ Beg, MK Siddiqi, SK Chaturvedi… - Archives of biochemistry …, 2017 - Elsevier
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …

[PDF][PDF] Thiosemicarbazone Complexes as Versatile Medicinal Chemistry Agents: A Review.

SE Jamal, A Iqbal, KA Rahman… - Journal of Drug Delivery & …, 2019 - core.ac.uk
Acknowledgements-The authors are grateful to all the faculty members of Department of
chemistry, Integral University for their cooperation and support. They are also thankful to the …

Hydroxylated coumarin-based thiosemicarbazones as dual antityrosinase and antioxidant agents

S Masuri, B Era, F Pintus, E Cadoni… - International Journal of …, 2023 - mdpi.com
The design of novel antityrosinase agents appears extremely important in medical and
industrial sectors because an irregular production of melanin is related to the insurgence of …

Acetylcholinesterase and Aβ aggregation inhibition by heterometallic Ruthenium (II)–Platinum (II) polypyridyl complexes

NA Vyas, SB Singh, AS Kumbhar, DS Ranade… - Inorganic …, 2018 - ACS Publications
Two heteronuclear ruthenium (II)–platinum (II) complexes [Ru (bpy) 2 (BPIMBp) PtCl2] 2+(3)
and [Ru (phen) 2 (BPIMBp) PtCl2] 2+(4), where bpy= 2, 2′-bipyridine, phen= 1, 10 …

Novel isatin thiosemicarbazone derivatives as potent inhibitors of β-amyloid peptide aggregation and toxicity

M Sagnou, B Mavroidi, A Kaminari… - ACS Chemical …, 2020 - ACS Publications
Inhibition of β-amyloid peptide (Αβ) aggregation in Alzheimer's disease (AD) is among the
therapeutic approaches against AD which still attracts scientific research interest. In the …

Coumarin-based thiosemicarbazones as colorimetric and fluorescent “Turn on” chemosensors for fluoride ions and their applications in logic circuits

RD Alharthy, S Tariq, S Naseem, M Islam… - Journal of Molecular …, 2023 - Elsevier
Herein, we have reported two novel coumarin based thiosemicarbazones as anionic
sensors. The structural elucidation of the synthesized sensors is done by 1 HNMR, 13 …

[HTML][HTML] Synthesis, characterization, anticancer activity, molecular docking and DFT calculation of 3-acetylcoumarin thiosemicarbazones and Schiff's bases

AK Yadav, N Singh, M Silwal, A Adhikari, PN Yadav - Results in Chemistry, 2024 - Elsevier
The new thiosemicarbazones (3a-d) of 3-acetylumbelliferone and Schiff's bases (4a-b) of 3-
acetylcoumarin were synthesized, characterized by elemental analysis, UV–Vis, FT-IR …