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Coumarin linked heterocyclic hybrids: a promising approach to develop multi target drugs for Alzheimer's disease
Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for …
Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display
interesting pharmacological properties. Several natural, synthetic and semisynthetic …
interesting pharmacological properties. Several natural, synthetic and semisynthetic …
New organoruthenium (II) complexes containing N, X-donor (X= O, S) heterocyclic chelators: synthesis, spectral characterization, in vitro cytotoxicity and apoptosis …
G Kalaiarasi, MM Subarkhan, CKF Safwana… - Inorganica chimica …, 2022 - Elsevier
Four Schiff base ligands namely ((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene)
semicarbazide)(HL 1),((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene …
semicarbazide)(HL 1),((1E)-1-(1-(6-chloro-2-oxo-2H-chromen-3-yl) ethylidene …
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …
pathophysiologies. Compounds that modulate protein aggregation and interact with …
[PDF][PDF] Thiosemicarbazone Complexes as Versatile Medicinal Chemistry Agents: A Review.
SE Jamal, A Iqbal, KA Rahman… - Journal of Drug Delivery & …, 2019 - core.ac.uk
Acknowledgements-The authors are grateful to all the faculty members of Department of
chemistry, Integral University for their cooperation and support. They are also thankful to the …
chemistry, Integral University for their cooperation and support. They are also thankful to the …
Hydroxylated coumarin-based thiosemicarbazones as dual antityrosinase and antioxidant agents
The design of novel antityrosinase agents appears extremely important in medical and
industrial sectors because an irregular production of melanin is related to the insurgence of …
industrial sectors because an irregular production of melanin is related to the insurgence of …
Acetylcholinesterase and Aβ aggregation inhibition by heterometallic Ruthenium (II)–Platinum (II) polypyridyl complexes
Two heteronuclear ruthenium (II)–platinum (II) complexes [Ru (bpy) 2 (BPIMBp) PtCl2] 2+(3)
and [Ru (phen) 2 (BPIMBp) PtCl2] 2+(4), where bpy= 2, 2′-bipyridine, phen= 1, 10 …
and [Ru (phen) 2 (BPIMBp) PtCl2] 2+(4), where bpy= 2, 2′-bipyridine, phen= 1, 10 …
Novel isatin thiosemicarbazone derivatives as potent inhibitors of β-amyloid peptide aggregation and toxicity
Inhibition of β-amyloid peptide (Αβ) aggregation in Alzheimer's disease (AD) is among the
therapeutic approaches against AD which still attracts scientific research interest. In the …
therapeutic approaches against AD which still attracts scientific research interest. In the …
Coumarin-based thiosemicarbazones as colorimetric and fluorescent “Turn on” chemosensors for fluoride ions and their applications in logic circuits
Herein, we have reported two novel coumarin based thiosemicarbazones as anionic
sensors. The structural elucidation of the synthesized sensors is done by 1 HNMR, 13 …
sensors. The structural elucidation of the synthesized sensors is done by 1 HNMR, 13 …
[HTML][HTML] Synthesis, characterization, anticancer activity, molecular docking and DFT calculation of 3-acetylcoumarin thiosemicarbazones and Schiff's bases
The new thiosemicarbazones (3a-d) of 3-acetylumbelliferone and Schiff's bases (4a-b) of 3-
acetylcoumarin were synthesized, characterized by elemental analysis, UV–Vis, FT-IR …
acetylcoumarin were synthesized, characterized by elemental analysis, UV–Vis, FT-IR …