For generations researchers have been observing the dynamic processes of life through the
lens of a microscope. This has offered tremendous insights into biological phenomena that …

Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is
critical for regulating homeostatic cellular function and communication, and disruptions of …

Realizing the full potential of organoids and assembloids to model neural development and
disease will require improved methods for long-term, minimally invasive recording of …

Voltage imaging measures neuronal activity directly and holds promise for understanding
information processing within individual neurons and across populations. However, imaging …

Genetically encoded fluorescence lifetime biosensors have emerged as powerful tools for
quantitative imaging, enabling precise measurement of cellular metabolites, molecular …

A remaining challenge for genetically encoded voltage indicators (GEVIs) is the reliable
detection of excitatory postsynaptic potentials (EPSPs). Here, we developed ASAP5 as a …

Monitoring neural activity in individual neurons is crucial for understanding neural circuits
and brain functions. The emergence of optical imaging technologies has dramatically …

The normal functioning of every cell in the body depends on its bioelectric properties and
many diseases are caused by genetic and/or epigenetic dysregulation of the underlying ion …

Two-photon voltage imaging has long been heralded as a transformative approach capable
of answering many long-standing questions in modern neuroscience. However, exploiting …

In calcium imaging studies, Ca2+ transients are commonly interpreted as neuronal action
potentials (APs). However, our findings demonstrate that robust optical Ca2+ transients …