Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …

Background The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's
disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct …

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's
disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially …

The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …