Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …

Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Abstract N 6-Methyladenosine (m6A) is one of the most abundant internal chemical
modifications on eukaryote mRNA and is involved in numerous essential molecular …

Characterization of RNA modifications has identified their distribution features and
molecular functions. Dynamic changes in RNA modification on various forms of RNA are …

To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

In the last decade, the notion that mRNA modifications are involved in regulation of gene
expression was demonstrated in thousands of studies. To date, new technologies and …

Abstract N 6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism
and various biological processes, including gametogenesis and embryogenesis. However …