[HTML][HTML] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance

E Salta, O Lazarov, CP Fitzsimons, R Tanzi… - Cell Stem Cell, 2023 - cell.com
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

[HTML][HTML] Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease

O Lazarov, M Gupta, P Kumar, Z Morrissey… - Progress in …, 2024 - Elsevier
Here, we provide an in-depth consideration of our current understanding of engrams,
spanning from molecular to network levels, and hippocampal neurogenesis, in health and …

[HTML][HTML] Hesperidin improves memory function by enhancing neurogenesis in a mouse model of Alzheimer's disease

D Lee, N Kim, SH Jeon, MS Gee, YJ Ju, MJ Jung… - Nutrients, 2022 - mdpi.com
Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by
memory and cognitive impairments. Neurogenesis, which is related to memory and cognitive …

Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease

SS Shahid, Q Wen, SL Risacher, MR Farlow… - Brain, 2022 - academic.oup.com
Hippocampal subfields exhibit differential vulnerabilities to Alzheimer's disease-associated
pathology including abnormal accumulation of amyloid-β deposition and neurofibrillary …

Benefits of the neurogenic potential of melatonin for treating neurological and neuropsychiatric disorders

Y Potes, C Cachán-Vega, E Antuña… - International Journal of …, 2023 - mdpi.com
There are several neurological diseases under which processes related to adult brain
neurogenesis, such cell proliferation, neural differentiation and neuronal maturation, are …

Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease

P Chen, ZL Guo, B Zhou - Ageing research reviews, 2023 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia and seriously affects the
quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction …

Neural stem cells in the treatment of Alzheimer's disease: Current status, challenges, and future prospects

X Chen, S Jiang, R Wang, X Bao… - Journal of Alzheimer's …, 2023 - journals.sagepub.com
Alzheimer's disease (AD), a progressive dementia, is one of the world's most dangerous and
debilitating diseases. Clinical trial results of amyloid-β (Aβ) and tau regulators based on the …

[HTML][HTML] Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating neural stem cell activity

S Gillotin, V Sahni, T Lepko, MA Hanspal… - Ageing Research …, 2021 - Elsevier
Deficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental,
psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides …

[HTML][HTML] Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

N Baazaoui, K Iqbal - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious
onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are …

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice

X Wang, H **ao, Y Wu, L Kong, J Chen, J Yang… - … medicine and therapies, 2021 - Springer
Background Alzheimer's disease (AD) is the most common dementia worldwide, and there is
still no satisfactory drug or therapeutic strategy. Polygala tenuifolia is a traditional Chinese …