Protein phosphatases and kinases control multiple cellular events including proliferation,
differentiation, and stress responses through regulating reversible protein phosphorylation …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

The role of PPM1D mutations in de novo gliomagenesis has not been systematically
explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas …

The p53 transcription factor is a master regulator of cellular stress responses inhibited by
repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with …

A greater understanding of factors causing cancer initiation, progression and evolution is of
paramount importance. Among them, the serine/threonine phosphatase PPM1D, also …

DNA damage response (DDR) pathway protects cells from genome instability and prevents
cancer development. Tumor suppressor p53 is a key molecule that interconnects DDR, cell …

Drugging the p53 pathway has been a goal for both academics and pharmaceutical
companies since the designation of p53 as the 'guardian of the genome'. Through growing …

DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

Neurogenesis correlates closely with the recovery of neural function after brain ischemia but
the critical proteins and signaling pathways involved remain unclear. The phosphatase …

Prostate cancer (PCa) is a common malignant tumor of the male genitourinary system that
seriously affects the quality of life of patients. Studying the pathogenesis and therapeutic …