A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

The fight against diseases spread by mosquitoes and other insects has enormous
environmental, economic and social consequences. Chemical insecticides remain the first …

Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the
immunosuppressive tumor microenvironment and improve innate and adaptive antitumor …

Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast
Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P …

The development of chloroquine as an antimalarial drug and the subsequent evolution of
drug-resistant Plasmodium strains had major impacts on global public health in the 20th …

Malaria still has a devastating impact on public health and welfare in Cameroon. Despite the
increasing number of studies conducted on disease prevalence, transmission patterns or …

Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

Summary Background The borders of Thailand harbour the world's most multidrug resistant
Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for …

Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification
of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 …