Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …
direct action on the failing heart that is independent of changes in renal tubular function. In …
Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
Human cardiac metabolism
The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …
has been studied for decades. However, the bulk of studies have focused on animal models …
[HTML][HTML] Mitochondria as intracellular signalling organelles. An update
LD Popov - Cellular Signalling, 2023 - Elsevier
Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several
diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step …
diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step …
Proteomics of the heart
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
Raising NAD+ Level Stimulates Short-Chain Dehydrogenase/Reductase Proteins to Alleviate Heart Failure Independent of Mitochondrial Protein Deacetylation
BACKGROUND: Strategies to increase cellular NAD+ (oxidized nicotinamide adenine
dinucleotide) level have prevented cardiac dysfunction in multiple models of heart failure …
dinucleotide) level have prevented cardiac dysfunction in multiple models of heart failure …
Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and is
characterized by primary left ventricular hypertrophy usually caused by mutations in …
characterized by primary left ventricular hypertrophy usually caused by mutations in …
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948
KJ Filipski, LA Martinez-Alsina, MR Reese… - Journal of Medicinal …, 2024 - ACS Publications
Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative
regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized to treat cardio …
regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized to treat cardio …