A Concise Review of Synthetic Strategy, Mechanism of Action, and SAR Studies of Phthalazine Derivatives as Anticancer Agent

GC Arya, R Sharma, S Mehla - Letters in Drug Design & …, 2024 - benthamdirect.com
Background Colorectal cancer is the third foremost cause of death in women and men.
Globally, about 1.94 million colon cancer cases were diagnosed and around 0.93 million …

Facile synthesis, characterization, and antimicrobial evaluation of novel heterocycles, schiff bases, and N-nucleosides bearing phthalazine moiety

ME Azab, SA Rizk, NF Mahmoud - Chemical and Pharmaceutical …, 2016 - jstage.jst.go.jp
The present work describes convenient synthesis of the novel Schiff bases 5a and b by
reacting phthalazinones 4a and b with 4-methoxybenzaldehyde Reaction of the Schiff bases …

Synthesis and Evaluation of Pyrido [2, 3‐d] pyrimidine and 1, 8‐Naphthyridine Derivatives as Potential Antitumor Agents

MS Behalo, G Mele - Journal of Heterocyclic Chemistry, 2017 - Wiley Online Library
New series of pyrido [2, 3‐d] pyrimidine and 1, 8‐naphthyridine derivatives were
synthesized from 2‐amino‐6‐(phenoxathiin‐2‐yl)‐4‐(thiophene‐2‐yl) nicotinonitrile as …

Synthesis of Novel Phthalazine Derivatives as Potential Anticancer and Antioxidant Agents Based on 1‐Chloro‐4‐(4‐phenoxyphenyl) phthalazine

MS Behalo, IA Gad El‐karim… - Journal of Heterocyclic …, 2017 - Wiley Online Library
A new series of phthalazine derivatives was synthesized from the reaction of 1‐chloro‐4‐(4‐
phenoxyphenyl) phthalazine as a reactive starting material with different carbon, nitrogen …

Cardanol-based green nanovesicles with antioxidant and cytotoxic activities

MS Behalo, E Bloise, L Carbone, RD Sole… - Journal of …, 2016 - Taylor & Francis
This manuscript describes the preparation of green nanovesicles by using cardanol as
renewable starting material with embedded minor amounts of phthalazines, a class of …

Synthesis of novel phthalazine derivatives as pharmacological activities

AF Wasfy, AA Aly, MS Behalo… - Journal of Heterocyclic …, 2020 - Wiley Online Library
Phthalazine derivatives attached to amino acid derivatives were synthesized with high
yields. The reaction of phthalazine derivatives with different phthalyl and tosylamino acids …

Sonogashira Reaction: Synthesis of Novel Derivatives of 3‐Aryl‐Substituted 6‐Chloroimidazo [2, 1‐a] phthalazines Catalyzed by Pd‐Cu in Water

M Bakherad, S Karami, A Keivanloo - ChemistrySelect, 2018 - Wiley Online Library
Abstract The reaction of 1‐chloro‐4‐propargylaminophthalazine with various aryl halides
catalyzed by Pd− Cu in the presence of potassium carbonate, as the base, in water leads to …

Genotoxicity evaluation of a new phthalazine substituted β-lactam derivative in human lymphocytes

B Aygün, AA Berber, MA Doganci, N Berber… - Anais da Academia …, 2022 - SciELO Brasil
The aim of present study, to evaluate the genotoxic potential of 1-(4-(3, 3-dimethyl-1, 6-dioxo-
2, 3, 4, 6, 11, 13-hexahydro-1H-indazolo [1, 2b] phthalazine-13yl) phenyl)-2-phenylazetidine …

[PDF][PDF] Synthesis of novel series of phthalazine derivatives with antibacterial and antifungal evaluation

MA El-Hashash, AAF Wasfy, HI Mohamed… - Journal of Basic and …, 2017 - jbesci.org
The oxirane derivative (2) was allowed to react with 4-amino benzoic acid to yield β-amino
derivative (3). The hydrazide (5) was reacted with glucose, aromatic aldehyde …

[PDF][PDF] 1, 4-Disulfopiperazine-1, 4-diium chloride ([Piper-(SO3H) 2]. 2Cl) as an efficient ionic catalyst for synthesis of phthalazine derivatives

F Shirini, TG Koodehi, O Goli-Jolodar - Iranian Journal of Catalysis, 2017 - sid.ir
This article describe the applicability of 1, 4-disulfopiperazine-1, 4-diium chloride ([Piper-
(SO3H) 2]. 2Cl) as a green, versatile and Brönsted acidic ionic catalyst in the promotion of …