The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Over the past several decades, halogen bonding has become a standard 'tool'in
supramolecular chemistry and particularly in crystal engineering. Traditionally, the study of …

Halogen bonding is emerging as a significant driving force for supramolecular self-assembly
and has aroused great interest during the last two decades. Among the various halogen …

Fluorinated iodoarenes such as 1, 4-diiodotetrafluorobenzene (1, 4-FIB) and 1, 3, 5-
triiodotrifluorobenzene (1, 3, 5-FIB) were cocrystallized with the nitrosoguanidinate-nickel (II) …

Carbon-bound halogen atoms (iodine, bromine, chlorine, and occasionally fluorine) are
known to act as electron acceptors and form interactions with different species capable of …

Pharmaceutical cocrystals, a type of multicomponent crystalline material incorporating two or
more molecular and/or ionic compounds connected by noncovalent interactions (such as …

Several synthetic techniques are available for the preparation of halogen-bonded adducts,
including traditional solvent-evaporation methods and mechanochemistry. With the intention …

Cocrystals have been extensively used to improve the physicochemical properties and
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …