Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …
second most common form of acute leukemia in children. Despite this, very little …
Protein acylation: mechanisms, biological functions and therapeutic targets
S Shang, J Liu, F Hua - Signal Transduction and Targeted Therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
BET bromodomain inhibitors
Lysine acetylation creates docking sites for epigenetic reader domains of BET bromodomain
proteins that have emerged as principal regulators of linage specific gene transcription. The …
proteins that have emerged as principal regulators of linage specific gene transcription. The …
TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell carcinoma cell lines
Background & Aims We investigated the transcriptome of esophageal squamous cell
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
Stromal induction of BRD4 phosphorylation results in chromatin remodeling and BET inhibitor resistance in colorectal cancer
W Wang, YA Tang, Q **ao, WC Lee, B Cheng… - Nature …, 2021 - nature.com
BRD4, a Bromodomain and Extraterminal (BET) protein family member, is a promising anti-
cancer drug target. However, resistance to BET inhibitors targeting BRD4 is common in solid …
cancer drug target. However, resistance to BET inhibitors targeting BRD4 is common in solid …
Targeting Brd4 for cancer therapy: inhibitors and degraders
Bromodomain-containing protein 4 (Brd4) plays an important role in mediating the
expression of genes involved in cancers and non-cancer diseases such as inflammatory …
expression of genes involved in cancers and non-cancer diseases such as inflammatory …
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
J Lu, E Cannizzaro, F Meier-Abt, S Scheinost… - Nature cancer, 2021 - nature.com
Chronic lymphocytic leukemia (CLL) has a complex pattern of driver mutations and much of
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744) …
GS Sheppard, L Wang, SD Fidanze… - Journal of Medicinal …, 2020 - ACS Publications
The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains
two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under …
two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under …
Enhancer architecture and essential core regulatory circuitry of chronic lymphocytic leukemia
CJ Ott, AJ Federation, LS Schwartz, S Kasar… - Cancer cell, 2018 - cell.com
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define
the core transcriptional regulatory circuits of normal and malignant cells. Gene control …
the core transcriptional regulatory circuits of normal and malignant cells. Gene control …
BET proteins: Biological functions and therapeutic interventions
J Guo, Q Zheng, Y Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …