Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate
energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …