Microbes are ubiquitous in the natural environment of Caenorhabditis elegans. Bacteria
serve as a food source for C. elegans but may also cause infection in the nematode host …

The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

The simple animal host Caenorhabditis elegans utilizes its nervous system to respond to
diverse microbial cues, and can engage in a protective behavioral avoidance response to …

The nervous system regulates host immunity in complex ways. Vertebrate olfactory sensory
neurons (OSNs) are located in direct contact with pathogens; however, OSNs' ability to …

Mitochondrial perturbations within neurons communicate stress signals to peripheral
tissues, coordinating organismal-wide mitochondrial homeostasis for optimal fitness …

Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense
against infection and to microbiota homeostasis. Understanding the mechanisms that …

Emerging evidence suggests that the microbiota present in feces plays a role in Parkinson's
disease (PD). However, the alterations of the microbiome in the blood of PD patients remain …

The mechanisms that tightly control the transcription of host defense genes have not been
fully elucidated. We previously identified TFEB as a transcription factor important for host …