Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in
prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid …

Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical'role of
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of a unique
repeated heptad sequence of the consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7. An …

Remote organ injury, which is a common secondary complication of sterile tissue damage, is
a major cause of poor prognosis and is difficult to manage. Here, we report the critical role of …

Terminal differentiation requires massive restructuring of the transcriptome. During intestinal
differentiation, the expression patterns of nearly 4,000 genes are altered as cells transition …

The MEK1/2–ERK1/2 pathway has been implicated in regulating the inflammatory response
to lung injury and infection, and pharmacologic MEK1/2 inhibitor compounds are reported to …

In recent years, plant-derived extracts are increasing interest from researchers worldwide
due to good efficacy and lower side effects. Among the different plant extracts, Dracorhodin …

Chromatin immunoprecipitation (ChIP) is the most widely used approach for identification of
genome-associated proteins and their modifications. We have previously introduced a …

Sepsis is the leading cause of death in intensive care units worldwide. Current treatments of
sepsis are largely supportive and clinical trials using specific pharmacotherapy for sepsis …

Background Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic
malignancy that is most commonly observed in children. Alantolactone (ALT) has been …