Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …

Melanocortin 4 receptor (MC4R) mutations are the most common cause of human
monogenic obesity and are associated with hyperphagia and increased linear growth. While …

Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs)
could help sustain such states by coupling slow-timescale molecular signals to neuronal …

The sense of hearing originates in the cochlea, which detects sounds across dynamic
sensory environments. Like other peripheral organs, the cochlea is subjected to …

Inhibition of appetite is an effective approach to fight obesity. Recently, bile acids have been
reported to suppress appetite and alleviate obesity via the Takeda G protein-coupled …

Endogenous neuropeptides are uniquely poised to regulate neuronal activity and behavior
across multiple timescales. Traditional studies ascribing neuropeptide contributions to …

Psychosocial stress is considered a severe pathogenic factor of psychiatric disorders,
characterized by dysfunctions of cognitive, emotional, and social domains. Histaminergic …