In voltage-dependent Na, K, or Ca channels, the probability of opening is modified by the
membrane potential. This is achieved through a voltage sensor that detects the voltage and …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Interconversion between conductive and non-conductive forms of the K+ channel selectivity
filter underlies a variety of gating events, from flicker transitions (at the microsecond …

294a Tuesday, February 22, 2022 channel exhibits a domain-swapped relationship
between voltage-sensing and pore domains, with the voltage-sensors in an activated state …

Voltage-dependent potassium channels are essential for the generation of nerve impulses.
Voltage sensitivity is conferred by charged residues located mainly in the fourth …

Ion channels, like many other proteins, have moving parts that perform useful functions. The
channel proteins contain an aqueous, ion-selective pore that crosses the plasma …

Ion conduction and selectivity properties of KcsA, a bacterial ion channel of known structure,
were studied in a planar lipid bilayer system at the single-channel level. Selectivity …

An understanding of the nervous system at virtually any level of analysis requires an
understanding of its basic building block, the neuron. The third edition of From Molecules to …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Voltage-gated ion channels sense voltage by shuttling arginine residues located in the S4
segment across the membrane electric field. The molecular pathway for this arginine …