Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

A number of environmental factors have been associated with the development of IBD.
Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of …

Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

La pandemia por COVID-19 ha representado un duro golpe al sistema sanitario peruano, y
las estrategias implementadas para el control de la epidemia han sido insuficientes en el …

Preclinical studies targeting the adenosinergic pathway have gained much attention for their
clinical potential in overcoming tumor-induced immunosuppression. Here, we have …