COVID-19 vaccine development: milestones, lessons and prospects

M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …

The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects

B Lu, JM Lim, B Yu, S Song, P Neeli… - Frontiers in …, 2024 - frontiersin.org
Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …

A brief review on DNA vaccines in the era of COVID-19

M Shafaati, M Saidijam, M Soleimani, F Hazrati… - Future …, 2022 - Taylor & Francis
This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design
strategies are described, then specific issues related to the industrial production of DNA …

Improved DNA vaccine delivery with needle-free injection systems

C Ledesma-Feliciano, R Chapman, JW Hooper… - Vaccines, 2023 - mdpi.com
DNA vaccines have inherent advantages compared to other vaccine types, including safety,
rapid design and construction, ease and speed to manufacture, and thermostability …

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

B Israelow, T Mao, J Klein, E Song, B Menasche… - Science …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160
million infections and more than 3 million deaths worldwide. Although effective vaccines are …

Status report on COVID-19 vaccines development

A Kumar, WE Dowling, RG Román… - Current Infectious …, 2021 - Springer
Abstract Purpose of Review The emergence of the severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) has affected lives of billions of individuals, globally. There is …

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

Transdermal gene delivery

W Zhang, Y Jiao, Z Zhang, Y Zhang, J Yu… - Journal of Controlled …, 2024 - Elsevier
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …

Therapeutic efficacy of monoclonal antibodies and antivirals against SARS-CoV-2 Omicron BA. 1 in Syrian hamsters

R Uraki, M Kiso, M Imai, S Yamayoshi, M Ito… - Nature …, 2022 - nature.com
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
major antigen stimulating the host's protective immune response. Here we assessed the …

Nucleic acid-based vaccine platforms against the coronavirus disease 19 (COVID-19)

R Baghban, A Ghasemian, S Mahmoodi - Archives of Microbiology, 2023 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has infected 673,010,496
patients and caused the death of 6,854,959 cases globally until today. Enormous efforts …