Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the maturation of a
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …

Protein–protein interactions (PPIs) underlie most biological processes. An increasing
interest to investigate the unexplored potential of PPIs in drug discovery is driven by the …

Cushing's syndrome is associated with multisystem morbidity and, when suboptimally
treated, increased mortality. Medical therapy is an option for patients if surgery is not …

Cushing's disease results from corticotroph adenomas of the pituitary that hypersecrete
adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism …

The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone responsible for the
stability and function of a wide variety of client proteins that are critical for cell growth and …

In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for
favorable long-term outcomes, although this remains a challenging task. The differential …

Pituitary adenomas (PAs) can be classified as non-secreting adenomas, somatotroph
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …

Endogenous Cushing's syndrome (CS) is associated with morbidities (diabetes,
hypertension, clotting disorders) and shortens life because of infections, pulmonary …

Corticotroph tumours are primarily sporadic monoclonal neoplasms and only rarely found in
genetic syndromes. Recurrent mutations in the ubiquitin specific protease 8 (USP8) gene …

Endogenous Cushing's syndrome is a chronic disease associated with increased morbidity
and mortality if not appropriately treated. Recurrence and/or persistence of …