The Baculovirus Expression Vector System (BEVS), a mature foreign protein expression
platform, has been available for decades, and has been effectively used in vaccine …

Vaccination is one of the most effective strategies to control epidemics. With the deepening
of people's awareness of vaccination, there is a high demand for vaccination. Hence, a …

Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of
triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian …

Targeted protein degradation is a new therapeutic modality based on drugs that destabilize
proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are …

Summary The N 6-methyladenosine (m 6 A) RNA modification is used widely to alter the fate
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …

Summary N 6-methyladenosine (m 6 A) is an essential internal RNA modification that is
critical for gene expression control in most organisms. Proteins with a YTH domain …

Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …

Flagellin, the protein subunit of the bacterial flagellum, stimulates the innate immune
receptor Toll-like receptor 5 (TLR5) after pattern recognition or evades TLR5 through lack of …

The concept of liquid–liquid phase separation (LLPS) has emerged as an intriguing
mechanism for the organization of membraneless compartments in cells. The alcohol 1, 6 …

Abstract Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its
role in regulating transcription of DNA-damage response (DDR) genes. However …