Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body
respond differentially to DNA damage. In this review, we will discuss how different SC …

The dogma that antineoplastic treatments kill tumour cells by damaging essential biological
functions has been countered by the notion that treatment itself initiates a programmed …

The small intestinal epithelium is the most rapidly self-renewing tissue of mammals.
Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy …

Adult stem cells (SCs) are at high risk of accumulating deleterious mutations because they
reside and self-renew in adult tissues for extended periods. Little is known about how adult …

The mature gut renews continuously and rapidly throughout adult life, often in a damage-
inflicting micro-environment. The major driving force for self-renewal of the intestinal …

Purpose: To conduct a literature review of candidate protein biomarkers for individual
radiation biodosimetry of exposure to ionizing radiation. Materials and methods …

Gap junctions are a unique type of intercellular channels that connect the cytoplasm of
adjoining cells. Each gap junction channel is comprised of two hemichannels or connexons …

Knowledge of the acute and late ionizing radiation exposure damage to the gastrointestinal
tract, particularly injury of the small intestine, is of great significance in radiotherapy, as is …

Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53
has widened to include the sensing of much more diverse forms of stress, including hypoxia …

The intestine is a highly radiosensitive tissue that is susceptible to structural and functional
damage due to systemic as well as localized radiation exposure. Unfortunately, no effective …