The role of inflammation and the gut microbiome in depression and anxiety

JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …

Mechanisms and therapeutic relevance of neuro-immune communication

SS Chavan, VA Pavlov, KJ Tracey - Immunity, 2017 - cell.com
Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

A meta-analysis of cytokines in Alzheimer's disease

W Swardfager, K Lanctôt, L Rothenburg, A Wong… - Biological …, 2010 - Elsevier
BACKGROUND: Studies suggest that inflammation is involved in the neurodegenerative
cascade leading to Alzheimer's disease (AD) pathology and symptoms. This study sought to …

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

VA Pavlov, KJ Tracey - Nature Reviews Endocrinology, 2012 - nature.com
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …

Reflex control of immunity

KJ Tracey - Nature Reviews Immunology, 2009 - nature.com
Inflammation can cause damage and even death. What controls this primitive and potentially
lethal innate immune response to injury and infection? Molecular and neurophysiological …

Cytokine targets in the brain: impact on neurotransmitters and neurocircuits

AH Miller, E Haroon, CL Raison… - Depression and …, 2013 - Wiley Online Library
Increasing attention has been paid to the role of inflammation in a host of illnesses including
neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory …

Molecular and functional neuroscience in immunity

VA Pavlov, SS Chavan, KJ Tracey - Annual review of …, 2018 - annualreviews.org
The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

Anti‐inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation

B Bonaz, V Sinniger, S Pellissier - The Journal of physiology, 2016 - Wiley Online Library
Brain and viscera interplay within the autonomic nervous system where the vagus nerve
(VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key …

Brain-gut interactions in inflammatory bowel disease

BL Bonaz, CN Bernstein - Gastroenterology, 2013 - Elsevier
Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role
in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves …

Neural regulation of immunity: molecular mechanisms and clinical translation

VA Pavlov, KJ Tracey - Nature neuroscience, 2017 - nature.com
Studies bridging neuroscience and immunology have identified neural pathways that
regulate immunity and inflammation. Recent research using methodological advances in …