Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …

Zea mays is an important genetic model for elucidating transcriptional networks.
Uncertainties about the complete structure of mRNA transcripts limit the progress of research …

Alternative splicing (AS) is a key regulatory mechanism that contributes to transcriptome and
proteome diversity. As very few genome-wide studies analyzing AS in plants are available …

Background Bamboo is one of the most important nontimber forestry products worldwide.
However, a chromosome-level reference genome is lacking, and an evolutionary view of …

Alternative splicing generates multiple transcript and protein isoforms from the same gene
and thus is important in gene expression regulation. To date, RNA-sequencing (RNA-seq) is …

Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic
disease (CMD) risk loci. However, they contribute little to genetic variance, and most …

Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences
(PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are …

Advances in transcriptomics have provided an exceptional opportunity to study functional
implications of the genetic variability. Technologies such as RNA-Seq have emerged as …