In mammals, loss of retinal cells due to disease or trauma is an irreversible process that can
lead to blindness. Interestingly, regeneration of retinal neurons is a well established process …

The adult mammalian central nervous system (CNS) is deficient in intrinsic machineries to
replace neurons lost in injuries or progressive degeneration. Various types of these neurons …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

The retina is a part of the brain that sits at the back of the eye, looking out onto the world. The
first neurons of the retina are the rod and cone photoreceptors, which convert changes in …

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for
neuron restoration therapies. Using lessons from regenerative species, we have developed …

Capture of a photon by an opsin visual pigment isomerizes its 11-cis-retinaldehyde
(11cRAL) chromophore to all-trans-retinaldehyde (atRAL), which subsequently dissociates …

Previous studies have demonstrated the dynamic changes in chromatin structure during
retinal development correlate with changes in gene expression. However, those studies lack …

Different kinase-dependent cell signaling pathways are known to play important roles in glia-
mediated neuroprotection and reprogramming of Müller glia (MG) into Müller glia-derived …

Mitochondrial networks remodel their connectivity, content, and subcellular localization to
support optimized energy production in conditions of increased environmental or cellular …

Retinal ganglion cell (RGC) differentiation is tightly controlled by extrinsic and intrinsic
factors. Growth and differentiation factor 15 (GDF-15) promotes RGC differentiation, opposite …