Role of metabolic H2O2 generation: redox signaling and oxidative stress
H Sies - Journal of Biological Chemistry, 2014 - ASBMB
Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …
Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide
Abstract Background Hydrogen peroxide (H 2 O 2) is an important signaling compound that
has recently been identified as a new substrate for several members of the aquaporin …
has recently been identified as a new substrate for several members of the aquaporin …
[HTML][HTML] Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function
Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …
Hydrogen peroxide–production, fate and role in redox signaling of tumor cells
C Lennicke, J Rahn, R Lichtenfels… - Cell communication and …, 2015 - Springer
Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …
Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages
ED Yoboue, R Sitia, T Simmen - Cell death & disease, 2018 - nature.com
Many cellular redox reactions housed within mitochondria, peroxisomes and the
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …
[HTML][HTML] Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Abstract Hydrogen peroxide (H 2 O 2) is an essential second intracellular messenger. To
reach its targets in the cytosol, H 2 O 2 must cross a membrane, a feat that requires …
reach its targets in the cytosol, H 2 O 2 must cross a membrane, a feat that requires …
The conundrum of hydrogen peroxide signaling and the emerging role of peroxiredoxins as redox relay hubs
S Stöcker, K Van Laer, A Mijuskovic… - Antioxidants & redox …, 2018 - liebertpub.com
Abstract Significance: Hydrogen peroxide (H2O2) is known to act as a messenger in signal
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum
Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …
of various redox reactions. Yet these products function as important signal messengers …
Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human …
J Kanner - Antioxidants, 2020 - mdpi.com
Human health benefits from different polyphenols molecules consumption in the diet,
derived mainly by their common activities in the gastrointestinal tract and at the level of …
derived mainly by their common activities in the gastrointestinal tract and at the level of …
Aquaporin water channels: Roles beyond renal water handling
FH Login, LN Nejsum - Nature Reviews Nephrology, 2023 - nature.com
Aquaporin (AQP) water channels are pivotal to renal water handling and therefore in the
regulation of body water homeostasis. However, beyond the kidney, AQPs facilitate water …
regulation of body water homeostasis. However, beyond the kidney, AQPs facilitate water …