Structure, mechanism, and dynamics of UDP-galactopyranose mutase
The flavoenzyme UDP-galactopyranose mutase (UGM) is a key enzyme in galactofuranose
biosynthesis. The enzyme catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to …
biosynthesis. The enzyme catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to …
Protein glycosylation in Leishmania spp.
Protein glycosylation is a co-and post-translational modification that, in Leishmania
parasites, plays key roles in vector–parasite–vertebrate host interaction. In the mammalian …
parasites, plays key roles in vector–parasite–vertebrate host interaction. In the mammalian …
[HTML][HTML] The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets
The heartworm Dirofilaria immitis is an important parasite of dogs. Transmitted by
mosquitoes in warmer climatic zones, it is spreading across southern Europe and the …
mosquitoes in warmer climatic zones, it is spreading across southern Europe and the …
Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae Family
MCM Motta, ACA Martins, SSA de Souza… - PloS one, 2013 - journals.plos.org
Endosymbiont-bearing trypanosomatids have been considered excellent models for the
study of cell evolution because the host protozoan co-evolves with an intracellular bacterium …
study of cell evolution because the host protozoan co-evolves with an intracellular bacterium …
Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule
MM Cámara, V Balouz… - PLoS Neglected …, 2019 - journals.plos.org
Background Trypanosoma cruzi, the agent of Chagas disease, is a protozoan parasite
transmitted to humans by blood-sucking triatomine vectors. However, and despite its utmost …
transmitted to humans by blood-sucking triatomine vectors. However, and despite its utmost …
Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period
V G. Duschak - Recent patents on anti-infective drug discovery, 2016 - benthamdirect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …
typically spread by triatomine vectors affecting millions of people all over Latin America …
Discovery and genetic validation of chemotherapeutic targets for Chagas' disease
There is an urgent need to develop new treatments for Chagas' disease. To identify drug
targets, it is important to understand the basic biology of Trypanosoma cruzi, in particular …
targets, it is important to understand the basic biology of Trypanosoma cruzi, in particular …
Stage-specific differential gene expression in Leishmania infantum: from the foregut of Phlebotomus perniciosus to the human phagocyte
Background Leishmania infantum is the etiological agent of zoonotical visceral
leishmaniasis in the Mediterranean basin. A recent outbreak in humans has been recently …
leishmaniasis in the Mediterranean basin. A recent outbreak in humans has been recently …
Identification of novel inhibitors against UDP‐galactopyranose mutase to combat leishmaniasis
Leishmania, a protozoan parasite that causes leishmaniasis, affects 1‐2 million people
every year worldwide. Leishmaniasis is a vector born disease and characterized by a …
every year worldwide. Leishmaniasis is a vector born disease and characterized by a …
Noncanonical reactions of flavoenzymes
P Sobrado - International Journal of Molecular Sciences, 2012 - mdpi.com
Enzymes containing flavin cofactors are predominantly involved in redox reactions in
numerous cellular processes where the protein environment modulates the chemical …
numerous cellular processes where the protein environment modulates the chemical …