Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Two-component systems are a dominant form of bacterial signal transduction. The
prototypical two-component system consists of a sensor that responds to a specific input (s) …

Two-component signal transduction systems enable bacteria to sense, respond, and adapt
to a wide range of environments, stressors, and growth conditions. In the prototypical two …

Two-component signal-transducing systems are ubiquitously distributed communication
interfaces in bacteria. They consist of a histidine kinase that senses a specific environmental …

Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …

Bacteria sense and respond to a wide range of physical and chemical signals. Central to
sensing and responding to these signals are two-component systems, which have a sensor …

The bacterial cell envelope is the first and major line of defence against threats from the
environment. It is an essential and yet vulnerable structure that gives the cell its shape and …

The ecological and evolutionary roles of antibiotics have been usually inferred from their
therapeutical activity. Since those compounds inhibit bacterial growth, it was thought that …

Feedback loops have been identified in a variety of regulatory systems and organisms.
While feedback loops of the same type (negative or positive) tend to have properties in …

Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening
infections caused by relevant Gram-positive human pathogens, such as Staphylococcus …