Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies
Asthma is a prevalent pulmonary disease that affects more than 300 million people
worldwide and imposes a substantial economic burden. While medication can effectively …
worldwide and imposes a substantial economic burden. While medication can effectively …
Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept
N Hernandez‐Pacheco, M Kere… - Pediatric Allergy and …, 2022 - Wiley Online Library
Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …
gene regulatory framework in response to environmental factors of relevance for childhood …
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
Multi‐ancestry genome‐wide association study of asthma exacerbations
Background Asthma exacerbations are a serious public health concern due to high
healthcare resource utilization, work/school productivity loss, impact on quality of life, and …
healthcare resource utilization, work/school productivity loss, impact on quality of life, and …
Severe asthma and biological therapies: now and the future
O Sardon-Prado, C Diaz-Garcia… - Journal of Clinical …, 2023 - mdpi.com
Recognition of phenotypic variability in pediatric asthma allows for a more personalized
therapeutic approach. Knowledge of the underlying pathophysiological and molecular …
therapeutic approach. Knowledge of the underlying pathophysiological and molecular …
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A
A Singla, S Reuter, C Taube, M Peters, K Peters - Inflammation Research, 2023 - Springer
Introduction Chronic inflammatory lung diseases are a common cause of suffering and
death. Chronic obstructive pulmonary disease (COPD) is the reason for 6% of all deaths …
death. Chronic obstructive pulmonary disease (COPD) is the reason for 6% of all deaths …
Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with …
Background Pharmacogenetic studies in asthma cohorts, primarily made up of White people
of European descent, have identified loci associated with response to inhaled beta agonists …
of European descent, have identified loci associated with response to inhaled beta agonists …
Genetic determinants of poor response to treatment in severe asthma
Severe asthma is a multifactorial disorder with marked phenotypic heterogeneity and
complex interactions between genetics and environmental risk factors, which could, at least …
complex interactions between genetics and environmental risk factors, which could, at least …
Multiomics analysis identifies BIRC3 as a novel glucocorticoid response–associated gene
Background Inhaled corticosteroid (ICS) response among patients with asthma is influenced
by genetics, but biologically actionable insights based on associations have not been found …
by genetics, but biologically actionable insights based on associations have not been found …
[HTML][HTML] Human genetics influences microbiome composition involved in asthma exacerbations despite inhaled corticosteroid treatment
J Perez-Garcia, A Espuela-Ortiz… - Journal of Allergy and …, 2023 - Elsevier
Background The upper-airway microbiome is involved in asthma exacerbations despite
inhaled corticosteroid (ICS) treatment. Although human genetics regulates microbiome …
inhaled corticosteroid (ICS) treatment. Although human genetics regulates microbiome …