Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …

Oxidative stress promotes genomic instability and human diseases. A common oxidized
nucleoside is 8-oxo-7, 8-dihydro-2′-deoxyguanosine, which is found both in DNA (8-oxo …

Nucleic acid polymerases catalyze the formation of DNA or RNA from nucleoside-
triphosphate precursors. Amino acid residues in the active site of polymerases are thought to …

DNA polymerase (pol) β is a small eukaryotic DNA polymerase composed of two domains.
Each domain contributes an enzymatic activity (DNA synthesis and deoxyribose phosphate …

The X family of DNA polymerases in eukaryotic cells consists of terminal transferase, and
DNA polymerases β, λ, and μ. These enzymes have similar structural portraits, yet different …

Recent years have seen an explosion in computer power, allowing for the examination of
ever more challenging problems. For instance, a recent simulation study, which was the first …

DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …

DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …

Recent years have seen dramatic improvements in computer power, allowing ever more
challenging problems to be approached. In light of this, it is imperative to have a quantitative …