Instrumentation at the leading edge of proteomics

TM Peters-Clarke, JJ Coon, NM Riley - Analytical Chemistry, 2024 - ACS Publications
The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

A comprehensive state-of-the-art survey on data visualization tools: Research developments, challenges and future domain specific visualization framework

HM Shakeel, S Iram, H Al-Aqrabi, T Alsboui… - IEEE Access, 2022 - ieeexplore.ieee.org
Data visualization is a powerful skill for the demonstration of meaningful data insights in an
interactive and effective way. In this survey article, we collected 70 articles from last five …

High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

K Frazier, A Kambal, EA Zale, JF Pierre, N Hubert… - Cell host & …, 2022 - cell.com
Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian
rhythms and metabolism ensuring optimal energy balance. However, the interplay between …

Discovery of a potent and selective targeted NSD2 degrader for the reduction of H3K36me2

RP Hanley, DY Nie, JR Tabor, F Li… - Journal of the …, 2023 - ACS Publications
Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene
regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2) …

RNA sequestration in P-bodies sustains myeloid leukaemia

S Kodali, L Proietti, G Valcarcel, AV López-Rubio… - Nature Cell …, 2024 - nature.com
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and
are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial …

Rapid multi-omics sample preparation for mass spectrometry

LK Muehlbauer, A Jen, Y Zhu, Y He… - Analytical …, 2023 - ACS Publications
Multi-omics analysis is a powerful and increasingly utilized approach to gain insight into
complex biological systems. One major hindrance with multi-omics, however, is the lengthy …

Hem25p is required for mitochondrial IPP transport in fungi

J Tai, RM Guerra, SW Rogers, Z Fang… - Nature cell …, 2023 - nature.com
Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor composed of a redox-active
quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access …

Regulated N-glycosylation controls chaperone function and receptor trafficking

M Ma, R Dubey, A Jen, GV Pusapati, B Singal… - Science, 2024 - science.org
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two
oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N …

Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency

AB Wass, BA Krishna, LE Herring, TSK Gilbert… - Science …, 2022 - science.org
Cytomegalovirus (CMV) reactivation from latency following immune dysregulation remains a
serious risk for patients, often causing substantial morbidity and mortality. Here, we …

[HTML][HTML] Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis

C Mathai, F Jourd'heuil, K Gilliard, D Howard, J Balnis… - Redox Biology, 2023 - Elsevier
Identifying novel regulators of vascular smooth muscle cell function is necessary to further
understand cardiovascular diseases. We previously identified cytoglobin, a hemoglobin …