[HTML][HTML] ARID1A gene mutation in ovarian and endometrial cancers
T Takeda, K Banno, R Okawa… - Oncology …, 2016 - spandidos-publications.com
The AT-rich interacting domain‑containing protein 1A gene (ARID1A) encodes ARID1A, a
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …
NOTCH1 signaling in head and neck squamous cell carcinoma
Biomarker-driven targeted therapies are lacking for head and neck squamous cell
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
L Liu, T Tao, S Liu, X Yang, X Chen, J Liang… - Nature …, 2021 - nature.com
Notch signaling represents a key mechanism mediating cancer metastasis and stemness.
To understand how Notch signaling is overactivated to couple tumor metastasis and self …
To understand how Notch signaling is overactivated to couple tumor metastasis and self …
Expression and role of Dickkopf-1 (Dkk1) in tumors: from the cells to the patients
G Zhu, J Song, W Chen, D Yuan, W Wang… - Cancer Management …, 2021 - Taylor & Francis
Abstract Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway.
Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal …
Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal …
Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas
Objectives Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are
distinct cancers in terms of a number of clinical and epidemiological characteristics …
distinct cancers in terms of a number of clinical and epidemiological characteristics …
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma
Objective While oesophageal squamous cell carcinoma remains infrequent in Western
populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to …
populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to …
[HTML][HTML] Driver genes in non-small cell lung cancer: characteristics, detection methods, and targeted therapies
QG Zhu, SM Zhang, XX Ding, B He, HQ Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung cancer is one of the most common causes of cancer-related death in the world. The
large number of lung cancer cases is non-small cell lung cancer (NSCLC), which …
large number of lung cancer cases is non-small cell lung cancer (NSCLC), which …
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
Background Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the
oral cavity, characterized by frequent recurrence and poor survival. The last three decades …
oral cavity, characterized by frequent recurrence and poor survival. The last three decades …
Notch1 mutations are drivers of oral tumorigenesis
Disruption of NOTCH1 signaling was recently discovered in head and neck cancer. This
study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell …
study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell …